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In fact, the metabolic changes in glucose, lipids, and amino acids provide the cancer cells with the energy and substances needed for biosynthesis and the maintenance of biological functions ( de novo cysteine synthesis from methionine which is recognized as an additional mechanism for maintaining cysteine pools in the tumor microenvironment ( N -methyltransferase may contribute to cysteine biosynthesis and promote cancer cell survival in cysteine-limited microenvironment, which has been demonstrated to support tumor growth in vivo ( Post-translational modifications targeting cysteine of protein in cancer PTMs is a biochemical modification occurring to one or more amino acids on a protein during or after protein translation